What question did this study set out to answer?

To determine whether pericardial fat impairs left ventricular (LV) function via systemic obesity or direct regional fat interactions by comparing fat adjacent to the left versus right ventricle in obese females.

May 23, 2014Journal of Cardiovascular Magnetic ResonanceOpen Access

The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect

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Population

60 obese females with no known cardiovascular disease, recruited from Boston Medical Center.

Design

Cross-sectional

Authors

NHNing HuaBoston University ZCZhongjing ChenChina Academy of Engineering Physics APAlkystis PhinikaridouKing's College London

Discussion

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Implication

Local LV fat may impair output in obese females independent of BMI; leaves open causality and need for longitudinal validation.

Key Points

To determine whether pericardial fat impairs left ventricular (LV) function via systemic obesity or direct regional fat interactions by comparing fat adjacent to the left versus right ventricle in obese females.
Evaluated N = 60 obese female subjects using cardiovascular magnetic resonance (CMR).
Measured LV functional parameters via cine steady-state free precession imaging in short-axis orientation.
Quantified pericardial fat volumes volumetrically using cardiac-gated T1 black blood imaging and normalized to body surface area.
LV fat negatively correlated with cardiac output (r = -0.41, p = 0.001) and stroke volume (r = -0.26, p = 0.05), remaining significant after controlling for body mass index and blood pressure.
LV fat correlated with impaired diastolic filling, including peak-early-filling rate (r = -0.38, p = 0.01), early-to-late filling ratio (r = -0.34, p = 0.03), and time to peak-early-filling (r = 0.34, p = 0.03), whereas correlations with right ventricular fat were weakened or absent.
LV function showed no significant correlation with circulating biomarkers, including C-reactive protein, B-type natriuretic peptide, interleukin-6, resistin, or adiponectin (all p > 0.05).

Structured PICO

Population

60 obese females (BMI ≥30 kg/m2, age 21-60 yrs) with no known cardiovascular disease, recruited from Boston Medical Center.

Outcome

Correlation between left ventricular (LV) function (cardiac output, stroke volume, diastolic parameters) and LV vs RV pericardial fat volumes measured by CMR.surrogate

Left ventricular function in obese females is more strongly associated with local left ventricular pericardial fat than right ventricular or total pericardial fat, independent of systemic inflammatory markers or overall obesity.

Limitations

Unable to distinguish epicardial fat from fat outside the pericardium in all subjects
Low temporal resolution of cine-CMR (28-30 ms) missing parameters like IVRT
Cross-sectional design cannot infer causality
Exclusion of male subjects due to scanner size limits
Did not consider conditions like sleep apnea or polycystic ovarian syndrome

Cite This Study

Hua et al. (2014) studied this question.

synapsesocial.com/papers/6a7245c4e36a167817e3c261 https://doi.org/10.1186/1532-429x-16-37

Topics

Cardiac MRI

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The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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Topics

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