Key result
High pericardial fat volume was associated with reduced diastolic function parameters, including lower e' lateral, compared to low pericardial fat volume in healthy subjects.
Why the study?
Pericardial fat has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction, but whether higher volume associates with lower diastolic function in healthy subjects was unknown.
Is a higher pericardial fat volume associated with lower diastolic function in healthy subjects?
Cross-Sectional (n=254)
No
Is a higher pericardial fat volume associated with lower diastolic function in healthy subjects?
Pericardial fat volume is independently associated with early subclinical changes in diastolic function parameters in healthy subjects, suggesting a potential mechanical constraint effect on the heart.
Answers are grounded in this paper and cite their sources.
Should not change clinical practice in healthy subjects; leaves open causal role of pericardial fat in diastolic dysfunction.
BACKGROUND: Pericardial fat (PF) has been suggested to directly act on cardiomyocytes, leading to diastolic dysfunction. The aim of this study was to investigate whether a higher PF volume is associated with a lower diastolic function in healthy subjects. All patients underwent a coronary computed tomographic angiography for the measurement of pericardial fat volume, as well as a transthoracic echocardiography for the assessment of diastolic function parameters. To assess the independent association of PF and diastolic function parameters, multivariable linear regression analysis was performed. To maximize differences in PF volume, the group was divided in low (lowest quartile of both sexes) and high (highest quartile of both sexes) PF volume. Multivariable binary logistic analysis was used to study the associations within the groups between PF and diastolic function, adjusted for age, BMI, and sex. RESULTS: Significant associations for all four diastolic parameters with the PF volume were found after adjusting for BMI, age, and sex. In addition, subjects with high pericardial fat had a reduced left atrial volume index (p = 0.02), lower E/e (p < 0.01) and E/A (p = 0.01), reduced e' lateral (p < 0.01), reduced e' septal p = 0.03), compared to subjects with low pericardial fat. CONCLUSION: These findings confirm that pericardial fat volume, even in healthy subjects with normal cardiac function, is associated with diastolic function. Our results suggest that the mechanical effects of PF may limit the distensibility of the heart and thereby directly contribute to diastolic dysfunction. Trial registration NCT01671930.
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Wit‐Verheggen et al. (2020) conducted a cross-sectional in Healthy subjects with (a)typical chest pain (n=254). High pericardial fat volume vs. Low pericardial fat volume was evaluated on e' lateral (cm/s) (p=<0.01). High pericardial fat volume was associated with reduced diastolic function parameters, including lower e' lateral, compared to low pericardial fat volume in healthy subjects.
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