Key result
AF linked to ~350% higher symptomatic stroke risk in 70-year-olds.
Why the study?
The mechanisms linking AF with cognitive decline and dementia remain unclear, prompting investigation into whether AF associates with cerebrovascular diseases beyond symptomatic stroke, including silent infarcts and small vessel disease markers.
Is atrial fibrillation associated with silent cerebrovascular disease and symptomatic stroke in 70-year-olds?
Cross-Sectional (n=776)
Is atrial fibrillation associated with silent cerebrovascular disease and symptomatic stroke in 70-year-olds?
Effect estimate: OR 4.5 (95% CI 2.1-9.5)
Atrial fibrillation is significantly associated with a broad range of cerebrovascular pathologies, including silent brain infarcts and lacunes, in 70-year-olds.
No takes yet. Share an insight, caveat, or question.
AF was associated with symptomatic and silent cerebrovascular disease in 70-year-olds; hypothesis-generating and should not yet change practice.
Rydén et al. (2021) conducted a cross-sectional in Atrial fibrillation and cerebrovascular disease (n=776). Atrial fibrillation vs. No atrial fibrillation was evaluated on Symptomatic stroke (OR 4.5, 95% CI 2.1-9.5). Atrial fibrillation was associated with symptomatic stroke (OR 4.5; 95% CI 2.1-9.5), large infarcts (OR 5.0), lacunes (OR 2.7), and silent brain infarcts (OR 3.5) in 70-year-olds.
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