Key result
Incident atrial fibrillation was associated with higher odds of an increase in subclinical cerebral infarctions (OR 3.08; 95% CI 1.39-6.83) and worsening sulcal and ventricular grades.
Why the study?
Atrial fibrillation is associated with dementia independent of clinical stroke, but the underlying mechanisms remain unclear.
Does incident or prevalent atrial fibrillation increase the risk of brain MRI abnormalities in a community-based cohort?
Cohort (n=963)
Does incident or prevalent atrial fibrillation increase the risk of brain MRI abnormalities in a community-based cohort?
Effect estimate: OR 3.08 (95% CI 1.39-6.83)
Atrial fibrillation is independently associated with an increase in subclinical cerebral infarctions and morphological brain changes associated with aging and dementia.
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Incident AF may accelerate subclinical brain injury on MRI; hypothesis-generating for cognitive outcomes in observational cohorts.
Berman et al. (2019) conducted a cohort in Atrial Fibrillation (n=963). Incident Atrial Fibrillation vs. No Atrial Fibrillation was evaluated on Increase in subclinical cerebral infarctions (OR 3.08, 95% CI 1.39-6.83). Incident atrial fibrillation was associated with higher odds of an increase in subclinical cerebral infarctions (OR 3.08; 95% CI 1.39-6.83) and worsening sulcal and ventricular grades.
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