June 17, 2003
View Full PaperAngiotensinogen Gene Polymorphism, Plasma Angiotensinogen, and Risk of Hypertension and Ischemic Heart Disease
Key Result
The angiotensinogen M235T TT genotype increased the risk of hypertension compared to the MM genotype in white (OR 1.19; 95% CI 1.10-1.30) and Asian (OR 1.60; 95% CI 1.19-2.15) populations.
Study Design
Type
Meta-Analysis
Structured PICO
Is the M235T polymorphism in the angiotensinogen gene associated with increased angiotensinogen levels, hypertension, and ischemic heart disease?
P
Population
127 studies published between January 1992 and March 2002 examining the association of angiotensinogen gene polymorphisms with cardiovascular endpoints in different ethnic populations (including white and Asian subjects)
I
Intervention
M235T polymorphism in the angiotensinogen gene (MT heterozygotes and TT homozygotes)
C
Comparator
MM genotype individuals
O
Outcome
Angiotensinogen levels, systolic and diastolic blood pressure, hypertension, and risk of ischemic cardiovascular disease or myocardial infarction
The angiotensinogen M235T genotype is associated with increased angiotensinogen levels and a higher risk of hypertension in white and Asian populations, but does not predict ischemic heart disease.
Main Result
Effect estimate: OR 1.19 (95% CI 1.10 to 1.30)
Abstract
OBJECTIVE: The aim of this study was to investigate whether the M235T polymorphism in the angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic blood pressure, hypertension, and risk of ischemic cardiovascular disease in different ethnic populations. METHODS AND RESULTS: One hundred twenty-seven studies published between January 1992 and March 2002 examining the association of angiotensinogen gene polymorphisms with the above-mentioned end points were selected. Pooled effect sizes and Mantel-Haenszel odds ratios were calculated using Review Manager. In white subjects, genotype was associated with a stepwise increase in plasma angiotensinogen levels of 5% (95% CI, 2% to 8%; P=0.0004) in MT heterozygotes and 11% (7% to 15%; P<0.00001) in TT homozygotes compared with MM individuals. Correspondingly, genotype was associated with a stepwise increase in aggregated odds ratio for hypertension of 1.08 (95% CI, 1.01 to 1.15) in MT individuals and 1.19 (1.10 to 1.30) in TT individuals in white subjects and of 1.29 (95% CI, 0.96 to 1.74) and 1.60 (1.19 to 2.15) in Asian subjects. M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group. CONCLUSIONS: Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects.
Cite This Study
Sethi et al. (Tue,) conducted a meta-analysis in Hypertension and Ischemic Heart Disease. Angiotensinogen M235T polymorphism (TT genotype) vs. MM genotype was evaluated on Hypertension (OR 1.19, 95% CI 1.10 to 1.30). The angiotensinogen M235T TT genotype increased the risk of hypertension compared to the MM genotype in white (OR 1.19; 95% CI 1.10-1.30) and Asian (OR 1.60; 95% CI 1.19-2.15) populations.