January 1, 1999Journal of Hypertension
M235T angiotensinogen gene polymorphism and cardiovascular renal risk
Why the study?
Does possession of the T allele of the M235T angiotensinogen gene polymorphism increase the risk of cardiovascular-renal disorders?
Population
27,906 subjects from 69 case-control studies
Comparison
Possession of the T allele of the M235T… vs MM genotype reference group
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
T allele marks hypertension risk in whites only; leaves open its role in cardiovascular-renal complications.
Structured PICO
Does possession of the T allele of the M235T angiotensinogen gene polymorphism increase the risk of cardiovascular-renal disorders?
P
Population
27,906 subjects from 69 case-control studies
I
Intervention
Possession of the T allele (TT homozygotes and TM heterozygotes) of the M235T angiotensinogen gene polymorphism
C
Comparator
MM genotype reference group
O
Outcome
Risk of cardiovascular-renal disorders including hypertension, atherosclerotic complications, renal microvascular disorders, cardiomyopathy, and diabetic retinopathy
The T allele of the M235T angiotensinogen gene polymorphism is a marker for hypertension in Caucasians but is not associated with atherosclerotic or microvascular complications.
Limitations
- Publication bias observed for hypertension
- Association does not necessarily imply causality
Cite This Study
Staessen et al. (1999) studied this question.