Key result
Elevated preoperative NT-proBNP predicts ~5-fold greater POAF risk after off-pump CABG.
Why the study?
Postoperative atrial fibrillation is a common complication after off-pump CABG, and whether elevated preoperative NT-proBNP levels can stratify risk needed evaluation.
Does a preoperative NT-proBNP level ≥388 pg/mL increase the risk of postoperative atrial fibrillation in patients undergoing off-pump CABG?
Cohort (n=512)
No
Does a preoperative NT-proBNP level ≥388 pg/mL increase the risk of postoperative atrial fibrillation in patients undergoing off-pump CABG?
Effect estimate: OR 5.72 (95% CI 3.24-10.48)
Absolute Event Rate: 39.1% vs 8.2%
p-value: p=<0.0001
Elevated preoperative NT-proBNP levels (≥388 pg/mL) strongly predict the development of postoperative atrial fibrillation in patients undergoing off-pump CABG.
No takes yet. Share an insight, caveat, or question.
Preoperative NT-proBNP ≥388 pg/mL was associated with POAF after off-pump CABG; hypothesis-generating and should not yet change practice.
Li et al. (2025) conducted a cohort in Off-pump coronary artery bypass grafting (CABG) (n=512). Preoperative NT-proBNP ≥ 388 pg/mL vs. Preoperative NT-proBNP < 388 pg/mL was evaluated on New onset of postoperative atrial fibrillation (POAF) lasting > 30 s during hospitalization (OR 5.72, 95% CI 3.24-10.48, p=<0.0001). A preoperative NT-proBNP level of 388 pg/mL or greater independently predicted a more than five-fold increased risk of postoperative atrial fibrillation (OR 5.72) in patients undergoing off-pump CABG.
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