What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery disease requiring off-pump coronary artery bypass grafting (n=100). Intervention: High preoperative NT-pro-BNP (>348 pg/mL) vs. Lower preoperative NT-pro-BNP (≤348 pg/mL). Primary outcome: Incidence of postoperative new-onset atrial fibrillation (OR 2.60, 95% CI 0.96-7.05, p=0.05).

December 25, 2012Annals of Thoracic and Cardiovascular SurgeryOpen Access

Preoperative High N-Terminal pro-B-Type Natriuretic Peptide Level Can Predict the Incidence of Postoperative Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

View Full Paper

Ask AI

Bookmark

Key result

High preoperative NT-pro-BNP levels (>348 pg/mL) independently predicted the incidence of postoperative new-onset atrial fibrillation following off-pump coronary artery bypass grafting (OR 2.60).

Why the study?

Does a high preoperative NT-pro-BNP level predict postoperative atrial fibrillation in patients undergoing off-pump coronary artery bypass grafting?

Population

100 patients undergoing off-pump coronary artery bypass grafting without preoperative atrial fibrillation…

Comparison

High preoperative NT-pro-BNP level vs Lower preoperative NT-pro-BNP level (≤348 pg/mL)

Design

Cohort, Assays were performed by a laboratory technician blinded to the…

Follow-up

at least 1 week postoperatively

Authors

KMKaoru MatsuuraKansai Medical University KMKenji MogiFunabashi Municipal Medical Center MSManabu SakuraiFunabashi Municipal Medical Center

Discussion

Member takes

Implication

May aid risk stratification for POAF after off-pump CABG; hypothesis-generating for targeted prophylaxis pending RCTs.

Study Design

Type

Observational (n=100)

Multicenter

Structured PICO

Does a high preoperative NT-pro-BNP level predict postoperative atrial fibrillation in patients undergoing off-pump coronary artery bypass grafting?

Population

100 patients undergoing off-pump coronary artery bypass grafting, free of preoperative atrial fibrillation and severe renal failure, monitored postoperatively for at least 1 week.

Exposure

High preoperative NT-pro-BNP level (>348 pg/mL, highest quartile)

Comparator

Lower preoperative NT-pro-BNP level (≤348 pg/mL)

Outcome

Incidence of postoperative new-onset atrial fibrillation (defined as an acute and sustained episode over 10 minutes requiring intervention)hard clinical

Main Result

Odds Ratio: 2.6 (95% CI 0.96–7.05)

p-value: p=0.05

Preoperative NT-pro-BNP levels greater than 348 pg/mL can independently predict the development of new-onset atrial fibrillation following off-pump coronary artery bypass grafting, identifying high-risk patients who may benefit from targeted prophylaxis.

Limitations

Small number of patients
Single institution study
Nonrandomized, retrospective design
Used a threshold of high quartile instead of an ROC curve to determine the NT-pro-BNP cutoff
Single institution
Nonrandomized, retrospective fashion
Possible bias caused by institutional standards and the patient population
Use of high quartile threshold instead of ROC curve

Cite This Study

Matsuura et al. (2012) conducted an observational in Coronary artery disease requiring off-pump coronary artery bypass grafting (n=100). High preoperative NT-pro-BNP (>348 pg/mL) vs. Lower preoperative NT-pro-BNP (≤348 pg/mL) was evaluated on Incidence of postoperative new-onset atrial fibrillation (OR 2.60, 95% CI 0.96-7.05, p=0.05). High preoperative NT-pro-BNP levels (>348 pg/mL) independently predicted the incidence of postoperative new-onset atrial fibrillation following off-pump coronary artery bypass grafting (OR 2.60).

synapsesocial.com/papers/6a8af70eb2ee551d2f336ddb https://doi.org/10.5761/atcs.oa.12.01994

Topics

Coronary artery disease Atrial fibrillation Persistent AF management

View Full Paper

Ask AI

Bookmark

Preoperative High N-Terminal pro-B-Type Natriuretic Peptide Level Can Predict the Incidence of Postoperative Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Preoperative High N-Terminal pro-B-Type Natriuretic Peptide Level Can Predict the Incidence of Postoperative Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider