Key result
Extrinsic sympathovagal nerve cryoablation eliminates paroxysmal AF episodes in paced canines from 4 to 0 daily.
Why the study?
The relationship between autonomic activation and the mechanisms of paroxysmal atrial fibrillation remains unclear.
Does cryoablation of extrinsic sympathovagal nerves prevent paroxysmal atrial fibrillation and tachycardia in ambulatory canines subjected to rapid atrial pacing?
Does cryoablation of extrinsic sympathovagal nerves prevent paroxysmal atrial fibrillation and tachycardia in ambulatory canines subjected to rapid atrial pacing?
Absolute Event Rate: 0% vs 4%
p-value: p=0.046
Cryoablation of extrinsic sympathovagal nerves eliminates pacing-induced paroxysmal atrial fibrillation and tachycardia in canines, demonstrating that simultaneous sympathovagal discharges are common triggers of these arrhythmias.
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Should not yet change practice; leaves open translation of sympathovagal cryoablation to human paroxysmal AF.
Tan et al. (2008) studied Paroxysmal atrial fibrillation and paroxysmal atrial tachycardia (n=13). Cryoablation of left and right stellate ganglia and cardiac branch of the left vagal nerve vs. No cryoablation was evaluated on Episodes of paroxysmal atrial fibrillation per day (p=0.046). Cryoablation of extrinsic sympathovagal nerves eliminated paroxysmal atrial fibrillation (0 vs 4 episodes/day, P=0.046) and paroxysmal atrial tachycardia (P<0.001) in paced canines.
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