Key result
Ischemic postconditioning significantly reduced infarct size at 6 months (11.8% vs 19.5%; P=0.04) and increased left ventricular ejection fraction by 7% at 1 year compared with control.
Why the study?
Does ischemic postconditioning reduce infarct size and improve long-term functional recovery in patients with acute myocardial infarction undergoing PCI?
RCT (n=38)
Does ischemic postconditioning reduce infarct size and improve long-term functional recovery in patients with acute myocardial infarction undergoing PCI?
Absolute Event Rate: 11.8% vs 19.5%
p-value: p=0.04
Ischemic postconditioning during primary PCI for STEMI significantly reduces infarct size at 6 months and improves left ventricular ejection fraction at 1 year.
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Supports ischemic postconditioning in primary PCI for STEMI; confirms long-term infarct size reduction and LVEF improvement in RCT.
Thibault et al. (2008) conducted an RCT in Acute myocardial infarction (n=38). Ischemic postconditioning vs. Control (no intervention) was evaluated on Infarct size assessed by single photon emission computed tomography rest-redistribution index at 6 months (p=0.04). Ischemic postconditioning significantly reduced infarct size at 6 months (11.8% vs 19.5%; P=0.04) and increased left ventricular ejection fraction by 7% at 1 year compared with control.
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