Key result
Postconditioning by coronary angioplasty significantly reduced infarct size by 36% (creatine kinase release AUC 208,984 vs 326,095) compared to control in acute myocardial infarction.
Why the study?
Does postconditioning by coronary angioplasty reduce infarct size in patients with acute myocardial infarction?
Population
30 patients undergoing coronary angioplasty for ongoing acute myocardial infarction.
Comparison
Postconditioning performed within 1 minute of… vs Control group receiving no further intervention…
Design
RCT, Randomly assigned
Follow-up
72 hours
Authors
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Supports adjunctive postconditioning during primary PCI; extends experimental data to randomized AMI patients.
RCT (n=30)
Randomized
Yes
Does postconditioning by coronary angioplasty reduce infarct size in patients with acute myocardial infarction?
Effect estimate: 36% reduction
Absolute Event Rate: 208984% vs 326095%
Ischemic postconditioning immediately after reperfusion during primary PCI for acute myocardial infarction significantly reduces infarct size.
Staat et al. (2005) conducted an RCT in Acute myocardial infarction (n=30). Postconditioning vs. No further intervention after reperfusion was evaluated on Infarct size assessed by area under the curve of total creatine kinase release over 72 hours (36% reduction). Postconditioning by coronary angioplasty significantly reduced infarct size by 36% (creatine kinase release AUC 208,984 vs 326,095) compared to control in acute myocardial infarction.
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