February 1, 1992Journal of Clinical InvestigationOpen Access

Chronic coronary artery constriction leads to moderate myocyte loss and left ventricular dysfunction and failure in rats.

View Full Paper

Ask AI

Bookmark

Why the study?

Does chronic coronary artery constriction lead to ventricular dysfunction, failure, and myocyte loss in rats?

Structured PICO

Does chronic coronary artery constriction lead to ventricular dysfunction, failure, and myocyte loss in rats?

Population

Male Sprague-Dawley rats at 2 months of age (n=34 total; 25 coronary narrowing, 9 sham-operated controls)

Intervention

Coronary artery narrowing (19% to 61% reduction in luminal diameter) induced by ligating the left coronary artery with a probe and removing the probe, evaluated 1 month later

Comparator

Sham-operated control rats (ligature positioned but not tied)

Outcome

Ventricular performance (LVEDP, LVPSP, DP, dP/dt), myocardial damage, and myocyte hypertrophy/loss at 1 monthsurrogate

Chronic coronary artery constriction in rats induces a spectrum of left ventricular dysfunction and failure characterized by moderate myocyte loss, reactive hypertrophy, and extensive ventricular remodeling.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Rat model quantifies myocyte loss thresholds in ischemic LV failure; leaves open human translation and therapeutic targeting.

Cite This Study

Anversa et al. (1992) studied this question.

synapsesocial.com/papers/6a10f789ed67694fb09fa981 https://doi.org/10.1172/jci115628

View Full Paper

Ask AI

Bookmark

Chronic coronary artery constriction leads to moderate myocyte loss and left ventricular dysfunction and failure in rats.

Structured PICO

Discussion

Implication

Cite This Study

Chronic coronary artery constriction leads to moderate myocyte loss and left ventricular dysfunction and failure in rats.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider