On the spontaneous reperfusion of infarct-related coronary artery during early hours of acute myocardial infarction.

Q: What does this research mean for the field?

Early spontaneous reperfusion during acute myocardial infarction accelerates the release of creatine phosphokinase (CPK) into the blood and leads to better preservation of chronic cardiac function compared to persistent occlusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Minoru Horie; Hirofumi Yasue; Shingo Omote; Akinori Takizawa; Masao Nagao; Shinichiro Nishida; Jiro Kubota; Akira Tanaka

doi:10.2169/naika.74.1231

January 1, 1985Nihon Naika Gakkai ZasshiOpen Access

On the spontaneous reperfusion of infarct-related coronary artery during early hours of acute myocardial infarction.

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Why the study?

Does early spontaneous reperfusion or successful PTCR improve chronic phase cardiac function in patients with first transmural myocardial infarction?

Structured PICO

Does early spontaneous reperfusion or successful PTCR improve chronic phase cardiac function in patients with first transmural myocardial infarction?

P

Population

69 patients with first transmural myocardial infarction (42 underwent coronary angiography within 8 hours of onset, 27 did not undergo PTCR)

I

Intervention

Spontaneous reperfusion (SR) or successful percutaneous transluminal coronary recanalization (PTCR)

C

Comparator

Coronary occlusion or delayed peak CPK

O

Outcome

Chronic phase cardiac function and time from onset to peak blood creatine phosphokinase (CPK)surrogate

Early spontaneous reperfusion accelerates CPK washout and is associated with better preserved chronic cardiac function in acute myocardial infarction.

Implication

Supports preserved chronic function with reperfusion at equivalent CPK; leaves open causal confirmation in randomized trials.

Abstract

初回貫壁性梗塞69名において血中creatine phosphokinase遊出動態と,その慢性期心機能との関係から責任冠動脈の早期spontaneous reperfusion(SR)について検討した.急性期(発症8時間以内)に冠動脈造影法を施行した42名では, PTCR成功例において閉塞例におけるより,発症から血中CPKが頂値に達するまでの時間は有意に短かく, SR例では前記の中間値を示した.同一のpeak CPKレベルでは, SR群, PTCR成功群で,また, PTCR未施行の27名では, CPK peak早期到達群でおのおの閉塞群, peak到達群遅延群におけるより慢性期心機能は良好に保たれていた.すなわちPTCR以外にも,早期のSRが存在し,血中へのCPK遊出を早め,ひいてはpeak CPKと心機能の相関に変化を与えたと考えられた.

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Cite This Study

Horie et al. (1985) studied this question.

synapsesocial.com/papers/6a10f789ed67694fb09fa990 https://doi.org/10.2169/naika.74.1231

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On the spontaneous reperfusion of infarct-related coronary artery during early hours of acute myocardial infarction.

Structured PICO

Implication

Abstract

Discussion

Cite This Study

On the spontaneous reperfusion of infarct-related coronary artery during early hours of acute myocardial infarction.

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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