Why the study?
Does monoclonal antibody M7/20 prolong cardiac allograft survival in mice?
Does monoclonal antibody M7/20 prolong cardiac allograft survival in mice?
Targeting the IL-2 receptor with a monoclonal antibody significantly prolongs cardiac allograft survival in a murine model, highlighting its potential as a target for immunosuppressive therapy.
Supports IL-2 receptor targeting for immunosuppression; hypothesis-generating and requires human trials before any practice change.
Administration of the monoclonal antibody M7/20, which binds to the murine interleukin-2 (IL) receptor, significantly prolongs cardiac allograft survival in two H-2-incompatible strain combinations of inbred mice. The results support the important role of the IL-2 receptor in the mechanism of graft rejection, and suggest its suitability as a target for immunosuppressive therapy.
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Kirkman et al. (1985) studied this question.
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