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Recent researches revealed that phosphoinositide 3‐kinase/protein kinase B (PI3K/Akt) plays an important role in the development of drug resistance, reducing the anti‐tumour activity of cytotoxic drugs, such as docetaxel (DTX). The aim of this reported work has been to evaluate DTX and the PI3K/Akt inhibitor perifosine co‐loaded Fol/R 7 (folate/R 7 ) nanoparticles (NPs) for enhancing anti‐cancer activity. The NPs were evaluated by size, zeta potential and morphology. Then cell viability, cellular uptake and apoptosis were performed in MCF‐7 and MCF‐7/Adr cells. The PI3K/Akt inhibition effect was assessed by western blotting. Compared with other experimental groups, DTX and perifosine loaded Fol/R 7 NPs displayed the highest cytotoxicity, cell uptake and early apoptosis in MCF‐7/Adr cells. Furthermore, the PI3K/Akt inhibition effect was enhanced by the Fol/R 7 NPs compared with the free drug group. The DTX and perifosine co‐loaded Fol/R 7 NPs could be a potential, safe and efficient option for enhancing anti‐cancer activity.
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Chen et al. (2015) studied this question.
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