Key result
A review of sepsis-induced myocardial dysfunction highlights that the mechanisms of cardiac depression and the clinical impact of diagnostic biomarkers remain unclear.
The mechanisms of myocardial dysfunction in sepsis and the clinical utility of biomarkers for its detection remain incompletely understood.
Biomarker interpretation in sepsis-induced myocardial dysfunction warrants caution; leaves open mechanistic understanding and diagnostic validation.
Sepsis has high incidence and mortality rates around the world. The role of cardiac depression in myocardial dysfunction during sepsis remains to be elucidated. This review attempts to summarize our understanding of the anatomical, histopathological, and pathophysiological mechanisms behind cardiac dysfunction. Biomarkers to detect cardiac depression have been used to recognize developing problems, but the actual impact of these tools remains unclear.
No takes yet. Share an insight, caveat, or question.
Fernandes et al. (2012) conducted a review in Sepsis with myocardial dysfunction. A review of sepsis-induced myocardial dysfunction highlights that the mechanisms of cardiac depression and the clinical impact of diagnostic biomarkers remain unclear.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: