What question did this study set out to answer?

To investigate the role of secreted frizzled-related protein 4 (sFRP4) in driving gastric cancer progression and resistance to cisplatin and oxaliplatin chemotherapy.

December 10, 2023Chemotherapy

Secreted Frizzled-Related Protein 4 Induces Gastric Cancer Progression and Resistance to Cisplatin and Oxaliplatin via β-Catenin Dysregulation

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Authors

CCChun‐Han ChenTaipei Medical University Hospital CCChih‐Jung ChenNational United University YHYi‐Ching HuangNational Chung Hsing University

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Implication

Preclinical study reveals that sFRP4 drives platinum resistance and metastasis in gastric cancer, indicating a potential target to overcome chemoresistance.

Key Points

To investigate the role of secreted frizzled-related protein 4 (sFRP4) in driving gastric cancer progression and resistance to cisplatin and oxaliplatin chemotherapy.
Assessed cell viability and drug resistance via MTT, colony formation, and Transwell cell migration assays using cisplatin- and oxaliplatin-resistant gastric cancer models.
Evaluated sFRP4 expression and β-catenin localization through Western blotting, immunohistochemistry of patient tumor tissues, and immunofluorescence staining.
sFRP4 was overexpressed in clinical gastric tumors and significantly correlated with poorer overall patient survival.
Cisplatin- and oxaliplatin-resistant gastric cancer cells showed upregulation and extracellular secretion of sFRP4 alongside nuclear translocation of β-catenin.
Elevated sFRP4 levels enhanced cancer cell migration and altered epithelial-mesenchymal transition markers, driving metastatic behavior.

Cite This Study

Chen et al. (2023) studied this question.

synapsesocial.com/papers/6a1100a95e6663f9d264d439 https://doi.org/10.1159/000533767

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Implication

Preclinical study reveals that sFRP4 drives platinum resistance and metastasis in gastric cancer, indicating a potential target to overcome chemoresistance.

Secreted Frizzled-Related Protein 4 Induces Gastric Cancer Progression and Resistance to Cisplatin and Oxaliplatin via β-Catenin Dysregulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Secreted Frizzled-Related Protein 4 Induces Gastric Cancer Progression and Resistance to Cisplatin and Oxaliplatin via β-Catenin Dysregulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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