Key result
The interactions of ACE I/D, eNOS 4 a/b, and ApoE gene polymorphisms do not play an important role in determining an individual's risk for the severity of coronary artery disease.
Why the study?
Do gene-gene interactions of ACE I/D, eNOS 4 a/b, and ApoE affect coronary artery disease severity in patients undergoing coronary angiography?
Observational (n=239)
No
Do gene-gene interactions of ACE I/D, eNOS 4 a/b, and ApoE affect coronary artery disease severity in patients undergoing coronary angiography?
While the ACE DD allele is associated with higher coronary and severity scores, interactions between ACE, eNOS, and ApoE polymorphisms do not significantly impact CAD severity.
These interactions should not guide CAD severity assessment; leaves open roles for individual variants like ACE DD in future studies.
OBJECTIVES: Previous studies have shown the impact of angiotensin converting enzyme (ACE) insertion/deletion (I/D), endothelial nitric oxide synthase (eNOS) polymorphisms and ApoE genotypes on coronary artery disease (CAD). The aim of this study is to investigate the relationship between the genetic polymorphisms and the severity of CAD and to evaluate their potential interactions. MATERIAL AND METHODS: All patients underwent coronary angiography; coronary score (CS) and severity score (SS) were calculated for them. ACE I/D, eNOS and ApoE polymorphisms were detected by polymerase chain reaction (PCR). RESULTS: Neither CS nor SS showed a direct relationship with eNOS and ApoE genotypes. CS and SS were found to be high in patients carrying the ACE DD allele (p = 0.034 and p = 0.009). In the gene interactions, there was an increase in the SS only in patients with coexisting eNOS b/b genotype and ACE DD allele (p = 0.043). CONCLUSIONS: The interactions of the gene polymorphisms investigated don't play an important role in determining an individual's risk for the severity of CAD.
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Matyar et al. (2014) conducted an observational in Coronary Artery Disease (n=239). ACE I/D, eNOS 4 a/b, and ApoE gene polymorphisms vs. Other genotypes was evaluated on Severity of coronary artery disease (Coronary Score and Severity Score) (p=0.043). The interactions of ACE I/D, eNOS 4 a/b, and ApoE gene polymorphisms do not play an important role in determining an individual's risk for the severity of coronary artery disease.
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