September 15, 2003HeartOpen Access

Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis

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Why the study?

Do variations and epistatic interactions in the ACE and AGTR1 genes affect the extent of coronary atherosclerosis in patients with coronary artery disease?

Structured PICO

Do variations and epistatic interactions in the ACE and AGTR1 genes affect the extent of coronary atherosclerosis in patients with coronary artery disease?

Population

1162 patients with coronary artery disease

Intervention

Presence of the D allele of the angiotensin I converting enzyme (ACE) gene and the +1166 C allele of the angiotensin II type 1 receptor (AGTR1) gene

Comparator

Absence of these alleles

Outcome

Coronary extent scores (defined as the number of coronary segments with 5% to 75% stenosis)surrogate

Gene-gene interactions between ACE and AGTR1 polymorphisms modify the severity and extent of coronary atherosclerosis in patients with CAD.

Discussion

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Implication

ACE/AGTR1 epistasis was associated with greater coronary extent; hypothesis-generating for genetic risk stratification in CAD.

Cite This Study

Shu Ye (2003) studied this question.

synapsesocial.com/papers/6a90d516263aa8e25c73c74d https://doi.org/10.1136/heart.89.10.1195

Topics

Coronary artery disease

View Full Paper

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Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis

Structured PICO

Discussion

Implication

Cite This Study

Topics

Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider