Key result
Microalbuminuria in type 2 diabetes patients was independently associated with increased carotid intimal-medial thickness (r=0.359, P<0.05), serving as an early sign of atherosclerosis.
Why the study?
Is microalbuminuria associated with increased carotid intimal-medial thickness and atherosclerosis in patients with type 2 diabetes mellitus?
Observational (n=250)
Is microalbuminuria associated with increased carotid intimal-medial thickness and atherosclerosis in patients with type 2 diabetes mellitus?
Effect estimate: r 0.359
p-value: p=<0.05
Microalbuminuria is significantly associated with increased carotid intimal-medial thickness, serving as an early indicator of carotid atherosclerosis in patients with type 2 diabetes.
Microalbuminuria may identify higher subclinical atherosclerosis risk in T2DM; leaves open causal links and outcome impact in prospective studies.
The aim of this study is to evaluate carotid atherosclerosis in patients of type 2 diabetes mellitus with microalbuminuria (MA) by high-frequency ultrasonography. Two hundred and fifty patients of type 2 diabetes mellitus were divided into two groups according to urinary albumin excretion rate (UAER): normoalbuminuria group (130 cases) and microalbuminuria group (120 cases). The intimal-medial thickness (IMT) and the atherosclerotic plaques of carotid artery were observed in both groups by high-frequency ultrasound. Fasting blood glucose (FBG), hemoglobin A1c, and lipid profiles were measured. The values of IMT of microalbuminuria group were significantly higher than those of normoalbuminuria group (P < 0.05). In univariate analysis, IMT was positively and significantly associated with age (r = 0.265, P < 0.05), waist circumference (r = 0.263, P < 0.05), body mass index (r = 0.285, P < 0.05), systolic blood pressure (r = 0.276, P < 0.05), UAER (r = 0.359, P < 0.05), HbA1c (r = 0.462, P < 0.05) and, duration of diabetes (r = 0.370, P < 0.05). In multivariate linear regression analysis, UAER and HbA1c were independent predictors of IMT (P < 0.05 for all). In the two groups, the rate of soft plaques was higher than that of dense plaques and calcified plaques. In conclusion, there is a significant association between microalbuminuria and IMT which is regarded as the early sign of carotid atherosclerosis in type 2 diabetic patients.
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Zhang et al. (2013) conducted an observational in Type 2 diabetes mellitus (n=250). Microalbuminuria vs. Normoalbuminuria was evaluated on Carotid intimal-medial thickness (IMT) and atherosclerotic plaques (r 0.359, p=<0.05). Microalbuminuria in type 2 diabetes patients was independently associated with increased carotid intimal-medial thickness (r=0.359, P<0.05), serving as an early sign of atherosclerosis.
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