Key result
Microalbuminuria in T2DM is linked to ~31% higher carotid intima-media thickness versus normoalbuminuria.
Why the study?
The study aimed to assess albuminuria as a predictor and independent marker of atherosclerosis in type 2 diabetes mellitus by measuring carotid intimal-medial thickness.
Is albuminuria associated with increased carotid intimal-medial thickness in patients with type 2 diabetes mellitus?
Cross-Sectional (n=120)
No
Is albuminuria associated with increased carotid intimal-medial thickness in patients with type 2 diabetes mellitus?
Absolute Event Rate: 0.94% vs 0.72%
p-value: p=< 0.05
Albuminuria is significantly associated with increased carotid intimal-medial thickness, suggesting it serves as a marker of atherosclerosis in patients with type 2 diabetes mellitus.
Albuminuria may flag higher atherosclerosis risk in T2DM; leaves open whether it improves risk stratification beyond standard markers.
Our aim in this study to assess the efficacy of albuminuria in type 2 diabetes mellitus to be as predictor and independent marker of atherosclerosis by measurement of carotid intimal-medial thickness (CIMT) by high frequency ultrasonography. One hundred twenty participants in this study, 45 as a control healthy person and the others 75 patients with type 2 diabetes mellitus were included in this study. We divided into three groups: group 1 which is the control group, and group 2 those patients who are the diabetic without albuminuria, and group 3 are the diabetic patients with albuminuria. The intimal-medial thickness (IMT) was measured by high frequency ultrasonography. Other laboratory investigations were measured like HbA1c, fasting blood sugar, lipid profile. The intimal-medial thickness (IMT) was found higher in group 3 than group 1 and group 2 (P value < 0.05). In conclusion, there is a significant association between micro- albuminuria and IMT as a marker of atherosclerosis in type 2 diabetes mellitus.
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A 2020 study conducted a cross-sectional in Type 2 diabetes mellitus (n=120). Microalbuminuria vs. Normoalbuminuria and healthy controls was evaluated on Carotid intimal-medial thickness (IMT) (p=< 0.05). Microalbuminuria in type 2 diabetic patients was associated with significantly higher carotid intima-media thickness (0.94 mm) compared to diabetic patients with normoalbuminuria (0.72 mm) and healthy controls (0.49 mm).
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