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October 19, 2005Diabetic Medicine

By multivariate analysis, urine albumin-creatinine ratio (ACR) was independently correlated with IMT (P < 0.001), with clinically significant differences associated with ACR > 0.65 mg/mmol (P < 0.01).

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Why the study?

Does urine albumin-creatinine ratio within the normal range correlate with carotid intima media thickness in adults with Type 2 diabetes?

Population

397 adults with Type 2 diabetes drawn from the Fenofibrate Intervention and Event Lowering in Diabetes…

Design

Cross-sectional

Authors

AKAnthony KeechSGStuart M. GrieveAPAnushka Patel

Discussion

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Member takes

Overview

May flag early atherosclerosis in T2DM via low-normal ACR; hypothesis-generating and should not yet change practice.

Structured PICO

Does urine albumin-creatinine ratio within the normal range correlate with carotid intima media thickness in adults with Type 2 diabetes?

P
Population
397 adults with Type 2 diabetes drawn from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study, evaluated prior to treatment allocation.
O
Outcome
Carotid intima media thickness (IMT)surrogate

In patients with Type 2 diabetes, urine albumin levels within the normal range are independently associated with increased carotid intima media thickness, suggesting a need for early cardiovascular disease evaluation.

Cite This Study

Keech et al. (2005) studied this question.

synapsesocial.com/papers/6a85ccb2c9698122d12dd473https://doi.org/10.1111/j.1464-5491.2005.01688.x
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