Key result
Properly treated normoglycemic women with GDM had no significant differences in carotid artery characteristics versus normal pregnant women (HbA1c 5.33 vs 5.36 mmol/L, p=0.85).
Why the study?
Does well-treated gestational diabetes mellitus alter morphological and functional characteristics of the common carotid artery compared to normal pregnancy?
Case-Control (n=42)
Does well-treated gestational diabetes mellitus alter morphological and functional characteristics of the common carotid artery compared to normal pregnancy?
Well-treated normoglycemic women with gestational diabetes mellitus do not show significant morphological or functional changes in large elastic arteries compared to non-diabetic pregnant women in the 3rd trimester.
Supports no carotid changes in treated normoglycemic GDM; leaves open long-term vascular risk in observational data.
Women with gestational diabetes mellitus (GDM) are at high risk of subsequently developing type 2 diabetes mellitus which is an important cardiovascular risk factor. We have evaluated whether preclinical morphological and functional arterial changes are present in GDM. Diameter, intima-media thickness (IMT), intima-media cross-section area (IMCSA) and elasticity features (compliance, distensibility coefficient, circumferential strain, stiffness index (SI) α and β, incremental elastic modulus) of the common carotid arteries (CCA) were studied in the 3rd trimester in 25 women with GDM, and 17 normal pregnant women matched for age and body mass index using an ultrasonographic vessel wall-movement tracking system and applanation tonometry. Mean IMT, IMCSA and SI α tended to be larger, whereas compliance was smaller in women with GDM but none of these differences were significant. Serum glucose (4.99 ± 0.51 vs. 4.79 ± 0.61 mmol/L, p=0.37) and HbA1c (5.33 ± 0.27 vs. 5.36 ± 0.47 mmol/L, p=0.85) proved normoglycemia in both groups. In conclusion, by the combination of methods we applied in this case control study, neither morphological nor functional characteristics of large elastic arteries differ significantly between well-treated normoglycemic women with GDM and non-diabetic pregnant women in the 3rd trimester.
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Vastagh et al. (2011) conducted a case-control in Gestational diabetes mellitus (n=42). Gestational diabetes mellitus vs. Normal pregnant women was evaluated on Morphological and functional characteristics of the common carotid arteries (Diameter, IMT, IMCSA, elasticity features). Properly treated normoglycemic women with GDM had no significant differences in carotid artery characteristics versus normal pregnant women (HbA1c 5.33 vs 5.36 mmol/L, p=0.85).
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