Key result
Type II diabetes mellitus was a strong independent predictor of advanced stenotic carotid atherosclerosis, increasing the odds 5-fold compared to normal glucose tolerance over 5 years.
Why the study?
Does previous gestational diabetes mellitus increase carotid intimal-medial thickness at one year postpartum in young Korean women?
Cohort (n=826)
Single-blind
No
Does previous gestational diabetes mellitus increase carotid intimal-medial thickness at one year postpartum in young Korean women?
Effect estimate: OR 5.0 (95% CI 2.3-11.1)
Absolute Event Rate: 52.5% vs 21.7%
p-value: p=<0.001
In young Korean women, previous gestational diabetes mellitus does not significantly increase carotid intimal-medial thickness at one year postpartum compared to normal pregnancies, although higher HbA1c is associated with increased CIMT.
T2DM warrants heightened carotid atherosclerosis vigilance; leaves open glycemic control's direct impact on progression.
BACKGROUND: Gestational diabetes mellitus (GDM) is known to increase the risk of cardiovascular diseases. Measuring the carotid artery intimal-medial thickness (CIMT) is a non-invasive technique used to evaluate early atherosclerosis and to predict future cardiovascular diseases. We examined the association between CIMT and cardiovascular risk factors in young Korean women with previous GDM. METHODS: One hundred one women with previous GDM and 19 women who had normal pregnancies (NP) were recruited between 1999 and 2002. At one year postpartum, CIMT was measured using high-resolution B-mode ultrasonography, and oral glucose tolerance tests were performed. Fasting glucose, glycated hemoglobin A1c (HbA1c), insulin levels and lipid profiles were also measured. CIMTs in the GDM and NP groups were compared, and the associations between CIMT and cardiovascular risk factors were analyzed in the GDM group. RESULTS: CIMT results of the GDM group were not significantly different from those of the NP group (GDM, 0.435±0.054 mm; NP, 0.460±0.046 mm; P=0.069). In the GDM group, a higher HbA1c was associated with an increase in CIMT after age adjustment (P=0.011). CIMT results in the group with HbA1c >6.0% were higher than those of the normal HbA1c (HbA1c ≤6.0%) (P=0.010). Nine of the patients who are type 2 diabetes mellitus converters within one year postpartum but showed no significant difference in CIMT results compared to NP group. CONCLUSION: Higher HbA1c is associated with an increase in CIMT in women with previous GDM. However, CIMT at one year postpartum was not increased in these women compared to that in NP women.
No takes yet. Share an insight, caveat, or question.
Ku et al. (2011) conducted a cohort in Carotid atherosclerosis (n=826). Type II diabetes mellitus vs. Normal glucose tolerance was evaluated on Incident advanced stenotic atherosclerosis (OR 5.0, 95% CI 2.3-11.1, p=<0.001). Type II diabetes mellitus was a strong independent predictor of advanced stenotic carotid atherosclerosis, increasing the odds 5-fold compared to normal glucose tolerance over 5 years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: