What question did this study set out to answer?

To determine whether women with a history of gestational diabetes mellitus exhibit higher epicardial fat thickness and carotid intima-media thickness compared to controls without such history.

March 26, 2014EchocardiographyOpen Access

Does Gestational Diabetes History Increase Epicardial Fat and Carotid Intima Media Thickness?

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Why the study?

Does a history of gestational diabetes mellitus increase epicardial fat thickness and carotid intima media thickness in women?

Population

95 women, comprising 62 patients with previous gestational diabetes mellitus and 33 age- and sex-matched…

Comparison

History of gestational diabetes mellitus (GDM) vs Age- and sex-matched controls without GDM history

Design

Case-control

Authors

MÇMustafa ÇalışkanIstanbul Medeniyet University ÖÇÖzge Telci ÇaklılıGirls Incorporated ZÇZuhal ÇalışkanUniversity of Health Science

Discussion

Member takes

Implication

Prior GDM may signal higher subclinical atherosclerosis risk; hypothesis-generating and should not yet change practice.

Key Points

To determine whether women with a history of gestational diabetes mellitus exhibit higher epicardial fat thickness and carotid intima-media thickness compared to controls without such history.
Enrolled 62 patients with prior gestational diabetes mellitus and 33 age- and sex-matched control individuals.
Measured epicardial fat thickness via transthoracic echocardiography, carotid intima-media thickness using ultrasound, and insulin resistance via HOMA-IR.
Carotid intima-media thickness and epicardial fat thickness were significantly elevated in the prior gestational diabetes group compared to controls.
Serum gamma-glutamyl transferase, uric acid, and high-sensitivity C-reactive protein levels were significantly higher in women with prior gestational diabetes than in controls.
Epicardial fat thickness was independently correlated with carotid intima-media thickness (β = 310, P = 0.003), total cholesterol (β = 315, P = 0.002), BMI (β = 308, P = 0.002), HbA1c (β = 227, P = 0.018), and HOMA-IR (β = 184, P = 0.049).

Structured PICO

Does a history of gestational diabetes mellitus increase epicardial fat thickness and carotid intima media thickness in women?

Population

95 women, comprising 62 patients with previous gestational diabetes mellitus (GDM) and 33 age- and sex-matched controls.

Intervention

History of gestational diabetes mellitus (GDM)

Comparator

Age- and sex-matched controls without GDM history

Outcome

Epicardial fat thickness (EFT) measured by transthoracic echocardiography and carotid intima media thickness (c-IMT) measured by ultrasoundsurrogate

Women with a history of gestational diabetes have higher epicardial fat and carotid intima-media thickness, suggesting an increased risk of subclinical atherosclerosis.

Limitations

Small sample size

Cite This Study

Çalışkan et al. (2014) studied this question.

synapsesocial.com/papers/6a70dac831a3df8243291a58 https://doi.org/10.1111/echo.12597

Topics

Echocardiography

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Does Gestational Diabetes History Increase Epicardial Fat and Carotid Intima Media Thickness?

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Does Gestational Diabetes History Increase Epicardial Fat and Carotid Intima Media Thickness?

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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