Why the study?
Do women with previous gestational diabetes mellitus have signs of subclinical atherosclerosis compared to women without previous gestational diabetes?
Do women with previous gestational diabetes mellitus have signs of subclinical atherosclerosis compared to women without previous gestational diabetes?
This study evaluates whether a history of gestational diabetes is associated with early subclinical atherosclerosis and adverse cardiovascular risk profiles 2 years postpartum.
Hypothesis-generating for postpartum CV risk after GDM; leaves open whether subclinical atherosclerosis warrants targeted screening or intervention.
To determine if women with previous gestational diabetes mellitus (pGDM), a population at high risk for type 2 diabetes and metabolic syndrome (1), have signs of subclinical atherosclerosis, we measured carotid intimal-medial thickness (IMT) and multiple cardiovascular risk factors in 28 women with and 24 without pGDM (control group) 2 years after delivery. A 75-g 2-h oral glucose tolerance test was performed for assessment of glucose tolerance, area under the glucose curve (AUCgluc), insulin sensitivity index, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, oxidized LDL (oxLDL), C-reactive protein (CRP), adiponectin, and fibrinogen. Family history, anthropometric parameters, and blood pressure were recorded. IMT was measured at four segments of …
No takes yet. Share an insight, caveat, or question.
Volpe et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: