Key result
Previous gestational diabetes mellitus was associated with slightly higher carotid intima media thickness and significantly lower percent of brachial flow mediated dilation compared to controls.
Why the study?
Does a previous history of gestational diabetes mellitus increase early atherosclerosis markers (CIMT and FMD) in women?
Observational
Does a previous history of gestational diabetes mellitus increase early atherosclerosis markers (CIMT and FMD) in women?
Women with a history of gestational diabetes exhibit signs of early atherosclerosis, including impaired endothelial function and increased insulin resistance, suggesting a need for cardiovascular follow-up.
Prior GDM may signal early vascular impairment; leaves open whether markers predict events or warrant targeted intervention.
AIM: Gestational diabetes mellitus (GDM) is a common pregnancy condition with long-term complications. We examined the association between inflammatory mediators and early atherosclerosis process by measuring the flow mediated dilatation (FMD) of brachial artery and carotid intima media thickness (CIMT) in women with previous GDM (pGDM). MATERIAL AND METHODS: Women with and without pGDM with an average of 4 years following the indexed pregnancy, participated in this study. Serum levels of IL-6, hs-CRP, adiponectin, homocystein and other biomedical parameters were measured. The existence of early atherogenesis process was evaluated by measuring CIMT and FMD. RESULTS: HOMA-IR and insulin were significantly higher in women with pGDM. Women with pGDM had slightly higher CIMT and significantly lower percent of brachial FMD. FMD and CIMT, adjusted for age and blood pressure, showed the same pattern. FMD showed no correlation with biochemical or inflammatory markers. CONCLUSION: Follow-up of this group of women, who are at increased risk of cardiovascular disease, with FMD should be considered.
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Fakhrzadeh et al. (2012) conducted an observational in Previous gestational diabetes mellitus. Previous gestational diabetes mellitus vs. Women without previous gestational diabetes mellitus was evaluated on Carotid intima media thickness (CIMT) and brachial flow mediated dilatation (FMD). Previous gestational diabetes mellitus was associated with slightly higher carotid intima media thickness and significantly lower percent of brachial flow mediated dilation compared to controls.
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