Key result
Youth with obesity and T2DM demonstrated greater carotid intima-media thickness and stiffness compared to lean youth (P<0.0001), partially explained by traditional cardiovascular risk factors.
Why the study?
Does obesity or type 2 diabetes mellitus increase carotid intima-media thickness and stiffness in youth compared to lean youth?
Population
446 youth (aged 10 to 24 years), comprising 182 lean, 136 obese, and 128 with type 2 diabetes mellitus (T2DM).
Comparison
Obesity or Type 2 Diabetes Mellitus vs Lean youth
Design
Cross-sectional
Authors
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May indicate early vascular risk in obese youth with T2DM; leaves open causal effects and intervention benefits.
Cross-Sectional (n=446)
Does obesity or type 2 diabetes mellitus increase carotid intima-media thickness and stiffness in youth compared to lean youth?
p-value: p=<0.0001
Youth with obesity and T2DM exhibit early vascular abnormalities, including increased carotid thickness and stiffness, highlighting the need for early cardiovascular risk factor management.
Urbina et al. (2009) conducted a cross-sectional in Obesity and Type 2 Diabetes Mellitus (n=446). Obesity and Type 2 Diabetes Mellitus vs. Lean youth was evaluated on Carotid intima-media thickness (cIMT) and stiffness (Young elastic modulus and beta stiffness index) (p=<0.0001). Youth with obesity and T2DM demonstrated greater carotid intima-media thickness and stiffness compared to lean youth (P<0.0001), partially explained by traditional cardiovascular risk factors.
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