Key result
Pharmacological interventions lowering blood glucose, platelet activation, or blood pressure significantly reduced carotid intima-media thickness progression (control rate 0.034 mm/y).
Why the study?
Do pharmacological interventions (glucose, platelet, or blood pressure lowering agents) reduce the progression of carotid intima-media thickness in patients with type 2 diabetes mellitus?
Population
11 studies pooling 1,578 subjects with type 2 diabetes mellitus
Comparison
Pharmacological interventions including agents… vs Control groups
Design
Meta-analysis
Authors
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Supports intensified glucose, platelet, or BP control in T2DM to slow atherosclerosis; reinforces cIMT as a modifiable surrogate in meta-analyses.
Do pharmacological interventions (glucose, platelet, or blood pressure lowering agents) reduce the progression of carotid intima-media thickness in patients with type 2 diabetes mellitus?
Pharmacological interventions targeting glucose, platelets, or blood pressure significantly reduce the progression of carotid intima-media thickness in patients with type 2 diabetes, independent of blood glucose control.
Yokoyama et al. (2006) conducted a review in Type 2 diabetes mellitus (n=1,578). Pharmacological interventions (blood glucose, platelet, or blood pressure lowering agents) vs. No intervention was evaluated on Rate of change in mean carotid intima-media thickness (CIMT) (95% CI 0.029 to 0.039). Pharmacological interventions lowering blood glucose, platelet activation, or blood pressure significantly reduced carotid intima-media thickness progression (control rate 0.034 mm/y).
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