Why the study?
Does established diabetes and higher fasting glucose level increase carotid intimal-medial wall thickness in persons with non-insulin-dependent diabetes mellitus?
Population
489 men and women of three different ethnic groups with non-insulin-dependent diabetes mellitus
Comparison
Established diabetes and mean fasting glucose… vs Newly diagnosed diabetes
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Links established diabetes to thicker carotid walls; supports hyperglycemia's role in atherosclerosis yet leaves open causal confirmation.
Key Points
- This research aims to explore the relationship between diabetes duration, hyperglycemia, and carotid wall thickness in individuals with diabetes.
- Cross-sectional analysis involving 489 participants with non-insulin-dependent diabetes
- Comparison of intimal-medial thickness (IMT) between established and newly diagnosed diabetics
- Assessment of the association between fasting glucose levels and IMT after adjusting for cardiovascular risk factors
- Mean CCA IMT in established diabetics was 872 microns; ICA IMT was 946 microns.
- Established diabetes increased CCA IMT by 70 microns compared to newly diagnosed diabetics (P < .05).
- Fasting glucose level increased CCA IMT by 26 microns per 1 SD increase, but diabetes duration did not significantly impact IMT.
Structured PICO
Does established diabetes and higher fasting glucose level increase carotid intimal-medial wall thickness in persons with non-insulin-dependent diabetes mellitus?
P
Population
489 men and women of three different ethnic groups with non-insulin-dependent diabetes mellitus (299 established diabetics, 190 newly diagnosed)
I
Intervention
Established diabetes (mean duration 7 years) and mean fasting glucose level (as measures of hyperglycemic burden)
C
Comparator
Newly diagnosed diabetes
O
Outcome
Intimal-medial wall thickness (IMT) of the internal (ICA) and common (CCA) carotid arteriessurrogate
Established diabetes and higher fasting glucose levels are independently associated with increased common carotid artery intimal-medial thickness, suggesting chronic hyperglycemia contributes to atherosclerosis risk.
Cite This Study
Wagenknecht et al. (1997) studied this question.