Key result
Post-transplant pathology confirms co-occurring myocardial sarcoidosis and LVNC in a patient with advanced HF.
Case Report (n=1)
No
This case highlights the rare co-occurrence of left ventricular non-compaction and cardiac sarcoidosis, emphasizing the importance of multimodality imaging and histopathology in diagnosing complex non-ischaemic cardiomyopathies.
A 46-year-old man with systolic heart failure, end-stage renal disease on dialysis, ventricular tachycardia and pulmonary sarcoidosis presented with decompensated heart failure and cardiogenic shock of unknown aetiology. The hospital course was complicated by worsening shock requiring inotropic and mechanical circulatory support, as well as eventual dual heart and kidney transplantation. Cardiac imaging was used to assess the aetiology of the patient's non-ischaemic cardiomyopathy, including a PET scan and cardiac MRI. Imaging demonstrated findings consistent with left ventricular non-compaction, but was inconclusive for cardiac sarcoidosis. After eventual heart transplantation, histopathology of the patient's explanted heart showed evidence of both non-compaction and cardiac sarcoidosis. In this case report, the authors review the pathophysiology of both cardiac sarcoidosis and left ventricular non-compaction, and highlight a multimodality approach to the diagnosis of non-ischaemic cardiomyopathy.
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Kumar et al. (2022) conducted a case report in Advanced Heart Failure, Myocardial Sarcoidosis, Left Ventricular Non-compaction (n=1). Dual heart and kidney transplantation was evaluated. A 46-year-old man with advanced heart failure was found to have co-occurring myocardial sarcoidosis and left ventricular non-compaction confirmed by gross pathology and histology after heart transplantation.
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