Key result
PVI plus LAPWI linked to reduced LRA, driven by roof and posterior regions.
Why the study?
To analyze, using non-contact charge density mapping, the changes in persistent AF induced by PVI and LA posterior wall isolation.
Does pulmonary vein isolation combined with LA posterior wall isolation change atrial fibrillation activation patterns compared to baseline and PVI alone in patients with persistent AF?
Observational (n=11)
Does pulmonary vein isolation combined with LA posterior wall isolation change atrial fibrillation activation patterns compared to baseline and PVI alone in patients with persistent AF?
The addition of posterior wall isolation to pulmonary vein isolation significantly reduces localized rotational activation in patients with persistent atrial fibrillation.
BACKGROUND: Non-contact charge density (CD) mapping allows a global visualization of left atrium (LA) activation and of activation patterns during atrial fibrillation (AF). The aim of this study was to analyze, with CD mapping, the changes in persistent AF induced by pulmonary vein isolation (PVI) and LA posterior wall isolation (LAPWI). METHODS: cryoballoon system were included in the study. CD maps were created during AF at baseline, after PVI and after LAPWI. Three distinct activation patterns were identified in the CD maps: localized irregular activation (LIA), localized rotational activation (LRA) and focal centrifugal activation (FCA). LA maps were divided into the following regions: anterior, septal, lateral, roof, posterior, inferior. RESULTS: Eleven patients were included, with a total of 33 maps and 198 AF regions analyzed. Global and regional AF cycle lengths significantly increased after PVI and LAPWI. Baseline analysis demonstrated higher LIA, LRA and FCA numbers in the posterior and anterior regions. After PVI, there was no change in LIA, LRA and FCA occurrence. After PVI + LAPWI, a significant decrease in LRA was observed with no difference in LIA and FCA occurrence. In the regional analysis, there was a significant reduction in the LIA number in the inferior region, in the LRA number in the roof and posterior regions and in the FCA number in the lateral region. CONCLUSIONS: A global reduction in the LRA number was observed only after PVI + LAPWI; it was driven by a reduction in rotational activity in the roof and posterior regions.
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Pannone et al. (2022) conducted an observational in Persistent atrial fibrillation (n=11). Pulmonary vein isolation (PVI) and left atrium posterior wall isolation (LAPWI) vs. Baseline and post-PVI alone was evaluated on Changes in localized irregular activation (LIA), localized rotational activation (LRA), and focal centrifugal activation (FCA) patterns. Pulmonary vein isolation combined with left atrium posterior wall isolation significantly reduced localized rotational activation, driven by reductions in the roof and posterior regions.
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