Key result
Acute isometric handgrip exercise failed to augment brachial artery flow-mediated dilation in young patients with congenital heart disease compared to healthy controls.
Why the study?
Does acute isometric handgrip exercise reveal vascular impairment in young patients with congenital heart disease compared to healthy controls?
Observational
Does acute isometric handgrip exercise reveal vascular impairment in young patients with congenital heart disease compared to healthy controls?
Young patients with congenital heart disease exhibit stress-induced conduit artery endothelial dysfunction despite intact microvascular function.
May indicate stress-induced endothelial dysfunction in congenital heart disease; leaves open utility of handgrip testing pending prospective validation.
Although young healthy control participants realize augmented brachial artery flow-mediated dilation following acute isometric handgrip exercise, young patients with congenital heart disease (CHD) fail to do so. Forearm microvascular function remains intact in congenital heart disease and is enhanced similarly to control participants following acute isometric handgrip exercise. Acute exercise may alter local regulatory mechanisms such that conduit artery endothelial-dependent vasodilation is not augmented, providing evidence of stress-induced vascular impairment in young patients with CHD.
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Khan et al. (2025) conducted an observational in Congenital heart disease. Acute isometric handgrip exercise vs. Healthy controls was evaluated on Brachial artery flow-mediated dilation and forearm microvascular function. Acute isometric handgrip exercise failed to augment brachial artery flow-mediated dilation in young patients with congenital heart disease compared to healthy controls.
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