Key result
Heat-moisture treated brown rice crackers increase postprandial FMD by ~1.4% versus standard rice crackers.
Why the study?
Endothelial dysfunction is an early pathophysiological feature and independent predictor of poor prognosis in most forms of cardiovascular disease.
Does heat-moisture treated brown rice crackers improve postprandial flow-mediated dilation in adults with mild endothelial dysfunction?
RCT (n=12)
Single-blind
Randomized
No
Does heat-moisture treated brown rice crackers improve postprandial flow-mediated dilation in adults with mild endothelial dysfunction?
Heat-moisture treated brown rice crackers may improve acute postprandial endothelial function in adults with mild endothelial dysfunction, potentially due to increased bioavailability of ferulic acids.
Answers are grounded in this paper and cite their sources.
May support dietary use of heat-moisture treated brown rice for endothelial health; extends RCT evidence on food processing and vascular function.
Background: Endothelial dysfunction is an early pathophysiological feature and independent predictor of a poor prognosis in most forms of cardiovascular disease. We evaluated the effect of brown rice crackers (BR-C) on endothelial function. Methods: Effect of heat-moisture treated (HMT) -BR-C on postprandial flow-mediated dilation (FMD) in adults with mild endothelial dysfunction was compared with that of BR-C and white rice crackers (WR-C) in 12 adults with mild endothelial dysfunction (less than 7.0% of FMD) by a randomized, single-blind, three-treatment three-period crossover trial (UMIN 000034898). Since we considered that the FMD increase was associated with the treatment of HMT-BR-C, we examined the effect of three possible factors: postprandial glucose levels, polyphenol content, and polyphenol release from the food matrix. Results: test). In comparison with BR-C, no significant difference was noted in the postprandial glucose level nor in the content of total polyphenols and ferulic acid derivatives in HMT-BR-C. However, the 70% ethanol extracted from HMT-BR-C contained a significantly larger amount of free and bound ferulic acids than from BR-C. Conclusion: HMT-BR-C intake increased the postprandial FMD response.
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Watanabe et al. (2022) conducted an RCT in Mild endothelial dysfunction (n=12). Heat-moisture treated brown rice crackers (HMT-BR-C) vs. Brown rice crackers (BR-C) and white rice crackers (WR-C) was evaluated on Flow-mediated dilation (FMD) at 1 hour post-intake (Effect size 0.63, p=0.042). Heat-moisture treated brown rice crackers significantly increased postprandial flow-mediated dilation from baseline by 1.4% (P=0.042), whereas brown and white rice crackers showed no significant change.
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