Key result
Intra-arterial infusion of L-NMMA significantly reduced postocclusion brachial artery vasodilatation after ischaemic handgrip exercise compared with NaCl infusion (P=0.039).
Why the study?
Does intra-arterial infusion of L-NMMA reduce postocclusion brachial artery vasodilatation after ischaemic handgrip exercise in healthy 60-year-old men?
Population
Healthy 60-year-old men
Comparison
Ischaemic handgrip exercise during… vs Ischaemic handgrip exercise during…
Design
Other
Authors
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May improve NO-dependent FMD quantification in research; leaves clinical utility open pending validation.
Does intra-arterial infusion of L-NMMA reduce postocclusion brachial artery vasodilatation after ischaemic handgrip exercise in healthy 60-year-old men?
p-value: p=0.039
Post-occlusion brachial artery vasodilatation after ischemic handgrip exercise is at least partly mediated by nitric oxide, offering a modified procedure to better quantify flow-mediated vasodilatation.
Agewall et al. (2002) studied Healthy. Intra-arterial infusion of L-NMMA during ischaemic handgrip exercise vs. Infusion of NaCl was evaluated on Postocclusion brachial artery vasodilatation (p=0.039). Intra-arterial infusion of L-NMMA significantly reduced postocclusion brachial artery vasodilatation after ischaemic handgrip exercise compared with NaCl infusion (P=0.039).
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