Key result
Endothelial nitric oxide synthase inhibition with L-NMMA reduced brachial artery vasodilation by approximately 70% at the highest handgrip exercise intensity compared to control.
Why the study?
Does endothelial NO synthase inhibition with L-NMMA reduce brachial artery vasodilation during progressive handgrip exercise in healthy young volunteers?
Population
8 young healthy volunteers, nonsmokers, normotensive, not participating in any regular exercise program…
Comparison
Progressive handgrip exercise with continuous… vs Progressive handgrip exercise without L-NMMA…
Design
Other
Follow-up
Acute (during exercise protocol)
Authors
Loading...
Supports handgrip exercise as noninvasive NO-dependent vasodilation probe; leaves open translation to clinical endothelial assessment.
Does endothelial NO synthase inhibition with L-NMMA reduce brachial artery vasodilation during progressive handgrip exercise in healthy young volunteers?
Absolute Event Rate: 3.3% vs 10.2%
p-value: p=<0.05
Progressive handgrip exercise provides a valid, noninvasive approach to assess NO-dependent vasodilation in humans, as eNOS inhibition abolishes the relationship between shear stress and brachial artery vasodilation.
Wray et al. (2011) studied Healthy volunteers (n=8). Intra-arterial L-NMMA vs. Control (no L-NMMA) was evaluated on Brachial artery vasodilation at the highest exercise intensity (24 kg) (p=<0.05). Endothelial nitric oxide synthase inhibition with L-NMMA reduced brachial artery vasodilation by approximately 70% at the highest handgrip exercise intensity compared to control.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: