Key result
Greater aortic stiffness (β 0.30, P=0.03) and lower proximal aortic compliance (β -0.63, P=0.001) were independently associated with faster aneurysm growth in bicuspid aortic valve patients.
Why the study?
Because aortic health is reflected in stiffness and pulsatile hemodynamics, researchers evaluated whether measures of aortic stiffness and arterial load associate with TAA growth in BAV.
Are measures of aortic stiffness and arterial load associated with thoracic aortic aneurysm growth in patients with bicuspid aortic valve?
Observational (n=29)
Are measures of aortic stiffness and arterial load associated with thoracic aortic aneurysm growth in patients with bicuspid aortic valve?
Effect estimate: β 0.30
p-value: p=0.03
In patients with bicuspid aortic valve and thoracic aortic aneurysm, increased aortic stiffness and decreased aortic compliance are associated with accelerated aneurysm expansion.
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Aortic stiffness measures may stratify growth risk in bicuspid aortic valve aneurysms; hypothesis-generating and requires prospective validation before clinical use.
Rooprai et al. (2019) conducted an observational in Thoracic aortic aneurysm due to bicuspid aortic valve (n=29). Aortic stiffness and pulsatile hemodynamics assessment was evaluated on Thoracic aortic aneurysm growth (β 0.30, p=0.03). Greater aortic stiffness (β 0.30, P=0.03) and lower proximal aortic compliance (β -0.63, P=0.001) were independently associated with faster aneurysm growth in bicuspid aortic valve patients.
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