Why the study?
Does intracoronary urokinase infusion improve coronary reperfusion in patients with acute myocardial infarction?
Population
63 patients with acute myocardial infarction treated within 184 +/- 70 min following onset of chest pain.
Design
Cohort
Follow-up
10-14 days
Authors
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May support intracoronary urokinase for AMI reperfusion; leaves open comparative efficacy versus modern therapies in RCTs.
Does intracoronary urokinase infusion improve coronary reperfusion in patients with acute myocardial infarction?
Intracoronary urokinase infusion effectively induces timely coronary reperfusion in acute myocardial infarction with a mild systemic lytic state and an 8% rate of hemorrhage requiring transfusion.
Cernigliaro et al. (1987) studied this question.
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