Why the study?
Does urokinase thrombolysis improve survival in patients with acute myocardial infarction compared to conventional therapy?
Population
244 patients with acute myocardial infarction (n=120 treated with urokinase, n=124 with conventional therapy)
Comparison
Urokinase administered within 6 hours of chest… vs Conventional therapy
Design
Cohort
Follow-up
20 months
Authors
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Associated with lower mortality in acute MI; hypothesis-generating and requires randomized confirmation.
Does urokinase thrombolysis improve survival in patients with acute myocardial infarction compared to conventional therapy?
Coronary thrombolysis with urokinase within 6 hours of symptom onset significantly reduces mortality in patients with acute myocardial infarction.
Katori et al. (1987) studied this question.
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