Why the study?
Does a lower dose of urokinase (2000 IU/kg/h) with heparin improve early revascularization compared to a higher dose of urokinase (4400 IU/kg/h) followed by heparin in patients with acute severe pulmonary embolism?
Population
129 patients with acute severe pulmonary embolism
Comparison
Urokinase 2000 IU kg−1 h−1 administered via a… vs Urokinase 4400 IU kg−1 h−1 administered via a…
Design
Other, Pulmonary angiograms analysed blindly by four independent vascular…
Follow-up
30 to 48 hours
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May support lower-dose urokinase plus heparin in acute PE; leaves open confirmation in larger randomized trials.
Does a lower dose of urokinase (2000 IU/kg/h) with heparin improve early revascularization compared to a higher dose of urokinase (4400 IU/kg/h) followed by heparin in patients with acute severe pulmonary embolism?
A lower dose of catheter-directed urokinase combined with heparin achieves similar angiographic resolution of severe pulmonary embolism compared to a higher dose of urokinase alone, with comparable bleeding risks.
A 1987 study studied this question.
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