Key result
A 2-hour urokinase regimen exhibited similar efficacy to the standard 12-hour regimen in patients with acute pulmonary embolism, showing comparable rates of improvement in pulmonary artery obstruction at 14 days (94.9% vs 91.4%, p=0.439).
Why the study?
Does a 2-hour urokinase regimen (20,000 U/kg) exhibit similar efficacy and safety compared to a 12-hour regimen (2,200 U/kg/h) in patients with acute pulmonary embolism?
Population
129 patients with acute pulmonary embolism (PE)
Comparison
Urokinase 20,000 U/kg infused over 2 hours vs Urokinase 2,200 U/kg/h infused over 12 hours
Design
RCT, Randomly assigned
Follow-up
14 days
Authors
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Supports accelerated 2-hour urokinase for acute PE; extends evidence for shorter thrombolytic regimens with comparable safety.
RCT (n=129)
Open-label
Computerized randomization program
Yes
Does a 2-hour urokinase regimen (20,000 U/kg) exhibit similar efficacy and safety compared to a 12-hour regimen (2,200 U/kg/h) in patients with acute pulmonary embolism?
Absolute Event Rate: 94.9% vs 91.4%
p-value: p=0.439
A 2-hour urokinase regimen demonstrates similar efficacy and safety to the standard 12-hour regimen for the treatment of acute pulmonary embolism.
Wang et al. (2009) conducted an RCT in Acute pulmonary embolism (n=129). Urokinase vs. Urokinase bolus 4,400 U/kg followed by 2,200 U/kg·h for 12 hours was evaluated on Any improvement in pulmonary artery obstruction at 14 days (p=0.439). A 2-hour urokinase regimen exhibited similar efficacy to the standard 12-hour regimen in patients with acute pulmonary embolism, showing comparable rates of improvement in pulmonary artery obstruction at 14 days (94.9% vs 91.4%, p=0.439).
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