Key result
Successful reperfusion with intracoronary urokinase in acute myocardial infarction resulted in better wall motion scores at one month compared to unsuccessful reperfusion (5.9 vs 3.6; P<0.05).
Why the study?
Does intracoronary urokinase infusion improve cardiac function in patients with evolving myocardial infarction?
Population
47 patients hospitalized within 12 hours from onset of chest pain with evolving myocardial infarction.
Comparison
Emergency coronary angiography and intracoronary… vs Compared by angiographic and reperfusion status…
Design
Cohort
Follow-up
1 to 30 months
Authors
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Supports improved LV function with successful reperfusion in AMI; leaves open causal benefit of intracoronary urokinase pending RCTs.
Observational (n=47)
Does intracoronary urokinase infusion improve cardiac function in patients with evolving myocardial infarction?
Absolute Event Rate: 5.9% vs 3.6%
p-value: p=<0.05
Early reperfusion by intracoronary urokinase infusion in acute myocardial infarction is associated with improved left ventricular function.
Kanmatsuse et al. (1984) conducted an observational in evolving myocardial infarction (n=47). Intracoronary urokinase (UK) infusion vs. Unsuccessful reperfusion was evaluated on Wall motion assessed by point-score system at one month (p=<0.05). Successful reperfusion with intracoronary urokinase in acute myocardial infarction resulted in better wall motion scores at one month compared to unsuccessful reperfusion (5.9 vs 3.6; P<0.05).
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