What question did this study set out to answer?

This study investigates the effects of aerobic conditioning on skeletal muscle and cardiovascular adaptations in older coronary patients.

August 1, 1996Circulation

Skeletal Muscle and Cardiovascular Adaptations to Exercise Conditioning in Older Coronary Patients

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Why the study?

Does a 3-month and 1-year program of intense aerobic exercise improve peak aerobic capacity and physiological adaptations in older coronary patients after myocardial infarction or coronary bypass surgery?

Population

70 older coronary patients beginning 8 +/- 5 weeks after myocardial infarction or coronary bypass surgery.

Comparison

3-month and 1-year program of intense supervised… vs Sedentary, age- and diagnosis-matched control…

Design

Cohort

Follow-up

1 year

Authors

PAPhilip A. AdesPreventive Cardiology MWMary L. WaldmannUniversity of Vermont WMWilliam L. MeyerAngelo State University

Discussion

Member takes

Implication

May support exercise programs targeting peripheral adaptations in older post-MI patients; leaves open causal confirmation and optimal regimens in RCTs.

Key Points

This study investigates the effects of aerobic conditioning on skeletal muscle and cardiovascular adaptations in older coronary patients.
60 older coronary patients underwent a 3-month and 1-year supervised exercise program after myocardial infarction or coronary bypass surgery.
Outcome measures included peak aerobic capacity, cardiac output, and skeletal muscle histology.
Results were compared with a control group of 10 matched sedentary individuals.
Peak aerobic capacity increased by 16% at 3 months and 20% at 1 year (P < .01).
Histochemical analysis revealed a 34% increase in capillary density and a 23% increase in succinate dehydrogenase activity after 3 months (both P < .02).
Individual fiber area increased by 29% after 12 months (P < .01).

Structured PICO

Population

70 older coronary patients (mean age, 68 +/- 5 years) beginning 8 +/- 5 weeks after myocardial infarction or coronary bypass surgery.

Intervention

3-month and 1-year program of intense supervised aerobic exercise.

Comparator

Sedentary, age- and diagnosis-matched control group.

Outcome

Peak aerobic capacity at 3 months and 1 year.surrogate

Intense aerobic exercise conditioning in older coronary patients significantly improves peak aerobic capacity primarily through peripheral skeletal muscle adaptations rather than central cardiac improvements.

Cite This Study

Ades et al. (1996) studied this question.

synapsesocial.com/papers/6a110bfebcb015a4461a11ab https://doi.org/10.1161/01.cir.94.3.323

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Implication

May support exercise programs targeting peripheral adaptations in older post-MI patients; leaves open causal confirmation and optimal regimens in RCTs.

Skeletal Muscle and Cardiovascular Adaptations to Exercise Conditioning in Older Coronary Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Skeletal Muscle and Cardiovascular Adaptations to Exercise Conditioning in Older Coronary Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider