Key result
Ischemic stroke linked to ~320% greater arrhythmia risk and increased heart failure versus controls.
Why the study?
Cardiac complications have been observed in patients with ischemic stroke in observational studies, prompting a systematic review and meta-analysis to investigate arrhythmias and heart failure in this population.
Does ischemic stroke increase the risk of cardiac complications such as arrhythmias and heart failure compared to controls?
Meta-Analysis (n=106,725)
Does ischemic stroke increase the risk of cardiac complications such as arrhythmias and heart failure compared to controls?
Patients with ischemic stroke are at a significantly increased risk of developing subsequent cardiac complications, including arrhythmias and heart failure.
Answers are grounded in this paper and cite their sources.
Patients with ischemic stroke warrant closer post-event cardiac monitoring; observational meta-analysis leaves open causal confirmation and intervention trials.
BACKGROUND: In patients with ischemic stroke (pwIS), cardiac complications have been observed in observational studies. We conducted a systematic review and meta-analysis to investigate the arrhythmias and heart failure in pwIS. METHODS: Up until September 2023, we searched for case-control, cross-sectional, or cohort studies in 4 databases. For case-control/cross-sectional studies, odds ratios (OR) were determined using a random-effects model meta-analysis, while hazard ratios (HR) were calculated for cohort studies, and 95% confidence intervals (CIs) were pooled in the meta-analysis. RESULTS: In the meta-analysis, we incorporated 5 studies: 2 cohort studies, 2 case-control studies, and 1 cross-sectional study. In all, 81,181 controls and 25,544 pwIS were included in this investigation. The combined OR for case-control studies of arrhythmias was estimated to be 1.86 (95% CI: 0.70-4.94, P = .21), HR for cohort studies of arrhythmias to be 4.2 (95% CI: 1.49-12.01, P < .05), and for cohort studies of heart failure to be 2.9 (95% CI: 2.65-3.18, P < .05), suggesting that pwIS may be more likely to experience cardiac complications. CONCLUSION: Our results revealed that there is a comparatively higher risk of cardiac complications in pwIS; however, more research is needed to evaluate the risk of cardiac complications in pwIS.
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Shah et al. (2024) conducted a meta-analysis in Ischemic stroke (n=106,725). Ischemic stroke vs. Controls was evaluated on Arrhythmias (cohort studies) (HR 4.2, 95% CI 1.49-12.01, p=<.05). Ischemic stroke was associated with a significantly higher risk of arrhythmias (HR 4.2; 95% CI 1.49-12.01; P<.05) and heart failure (HR 2.9; 95% CI 2.65-3.18; P<.05) compared to controls.
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