Key result
Coexisting raised blood pressure and plasma glucose synergistically accelerated the annual increase in pulse wave velocity compared to neither abnormality (68.3 vs 11.1 cm/s per year; P<0.01).
Why the study?
Does the combination of raised blood pressure and raised plasma glucose synergistically accelerate arterial stiffening in Japanese men?
Observational (n=2,080)
Does the combination of raised blood pressure and raised plasma glucose synergistically accelerate arterial stiffening in Japanese men?
Absolute Event Rate: 68.3% vs 11.1%
p-value: p=<0.01
The coexistence of raised blood pressure and fasting plasma glucose, even below thresholds for hypertension and diabetes, synergistically accelerates arterial stiffening.
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May identify combined mild elevations for closer monitoring; hypothesis-generating for synergistic intervention trials.
Tomiyama et al. (2005) conducted an observational in Arterial stiffness (n=2,080). Raised blood pressure and raised plasma glucose vs. Either abnormality alone or neither abnormality was evaluated on Annual rate of increase of the pulse wave velocity (PWV) (p=<0.01). Coexisting raised blood pressure and plasma glucose synergistically accelerated the annual increase in pulse wave velocity compared to neither abnormality (68.3 vs 11.1 cm/s per year; P<0.01).
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