Key result
Liver cancer is linked to ~12-fold higher cardiovascular mortality versus the general population.
Why the study?
Assessing cardiovascular mortality risk among liver cancer patients is crucial for understanding their overall health outcomes.
Do patients with liver cancer have a higher risk of cardiovascular mortality compared to the general population?
Cohort (n=70,733)
Yes
Do patients with liver cancer have a higher risk of cardiovascular mortality compared to the general population?
Effect estimate: SMR 12.01 (95% CI 11.48-12.55)
Liver cancer patients have a 12-fold higher risk of cardiovascular mortality compared to the general population, underscoring the need for targeted cardiovascular risk assessment and management in this cohort.
May warrant closer CV monitoring in liver cancer; leaves open whether interventions improve outcomes.
Crucial for understanding liver cancer patients overall health outcomes. This research aimed to assess the CVM risk of them. METHODS AND MATERIALS: Data sourced from the Surveillance, Epidemiology, and End Results (SEER) database encompassing liver cancer diagnoses from 2000 to 2017 were utilized. The standardized mortality rate (SMR) was computed using general population reference data, and multivariate competing risk models were employed for analysis. RESULTS: Analysis of 70,733 liver cancer patient records revealed 1,954 instances of CVM. The overall CVM SMR for liver cancer patients was 12.01 (95% CI: 11.48-12.55). Various demographic and clinical factors, including sex, race, age, year of diagnosis, pathological type, general stage, treatment modalities, and matrimonial status, emerged as liver cancer patients` independent predictors of CVM. CONCLUSION: Liver cancer patients have a notably heightened susceptibility to cardiovascular mortality (CVM) in contrast to the general populace. It is imperative to promptly recognize high-risk subcategories and execute tailored cardiovascular interventions as crucial measures to bolster survival rates within this cohort of patients.
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Li et al. (2024) conducted a cohort in Liver cancer (n=70,733). Liver cancer diagnosis vs. General population was evaluated on Cardiovascular mortality (CVM) (SMR 12.01, 95% CI 11.48-12.55). Liver cancer patients have a significantly heightened risk of cardiovascular mortality compared to the general population (SMR 12.01; 95% CI 11.48-12.55).
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