Key result
Bladder cancer was associated with a significantly increased risk of cardiovascular mortality compared to the general population (SMR 1.16; 95% CI 1.14-1.17).
Why the study?
The study was conducted to evaluate the risk of cardiovascular mortality among patients with bladder cancer.
Does bladder cancer increase the risk of cardiovascular mortality compared to the general population?
Observational (n=237,563)
Does bladder cancer increase the risk of cardiovascular mortality compared to the general population?
Effect estimate: SMR 1.16 (95% CI 1.14-1.17)
Patients with bladder cancer have a significantly increased risk of cardiovascular mortality compared to the general population, highlighting the potential need for cardiovascular protection interventions.
BACKGROUND: The purpose of this study was to evaluate the risk of cardiovascular mortality (CVM) among patients with bladder cancer (BC). METHODS AND MATERIALS: Data were collected from the Surveillance, Epidemiology, and End Results (SEER) database for patients who were diagnosed with BC by pathology between 2000 and 2016. The standardized mortality rate (SMR) was calculated based on reference data from the general population. Nelson-Aalen cumulative hazard curves were used to assess the risk of experiencing CVM in BC patients. Multivariate competing risk models were performed. RESULTS: In total, data from 237,563 BC patients were obtained from the SEER database for further analysis, of which 21,822 patients experienced CVM; the overall SMR for CVM in BC patients was 1.16 (95% CI: 1.14-1.17). Age, race, sex, year of diagnosis, histologic type, summary stage, surgery, marital status, and college education level were independent predictors of CVM in patients with BC. CONCLUSIONS: Patients with BC have a significantly increased risk of experiencing CVM compared to the general population. Pre-identification of high-risk groups and cardiovascular protection interventions are important measures to effectively improve survival in this group of patients.
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Shun-de et al. (2022) conducted an observational in Bladder cancer (n=237,563). Bladder cancer vs. General population was evaluated on Cardiovascular mortality (SMR 1.16, 95% CI 1.14-1.17). Bladder cancer was associated with a significantly increased risk of cardiovascular mortality compared to the general population (SMR 1.16; 95% CI 1.14-1.17).
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