Key result
Primary breast cancer was associated with a significantly higher risk of cardiovascular mortality compared to the general population (SMR 4.84; 95% CI 4.72-4.95).
Why the study?
Cardiovascular disease is the leading non-cancer cause of death in breast cancer patients, prompting investigation into their risk of cardiovascular mortality.
What is the risk and what are the predictors of cardiovascular mortality in patients with breast cancer compared to the general population?
Cohort (n=399,014)
Yes
What is the risk and what are the predictors of cardiovascular mortality in patients with breast cancer compared to the general population?
Effect estimate: SMR 4.84 (95% CI 4.72-4.95)
Breast cancer patients have a nearly 5-fold higher risk of cardiovascular mortality compared to the general population, highlighting the need for early detection and intervention of cardiovascular risk factors.
May warrant enhanced CV surveillance in breast cancer survivors; extends observational SMR data but leaves intervention effects open.
Background: Cardiovascular disease (CVD) is the leading cause of death for all non-cancer deaths among breast cancer (BC) patients. The aim of this study was to investigate the risk of cardiovascular mortality (CVM) in patients with BC. Methods: Patients diagnosed with primary BC between 2010 and 2018 were identified through the Surveillance, Epidemiology and End Results (SEER) database. The standardized mortality ratio (SMR) for CVD was calculated to compare the CVM of BC patients with that of the general population. Multivariate competing risk models were performed to identify predictors of CVM in BC patients. Results: Overall, 399,014 BC patients were included from the SEER database, of whom 7,023 (1.8%) suffered death from CVD. The significantly higher overall SMR of CVM was observed in BC patients [SMR =4.84, 95% confidence interval (CI): 4.72-4.95]. Multivariate competing risk regression analysis revealed that age, race, American Joint Committee on Cancer (AJCC) stage, year of diagnosis, estrogen receptor (ER) status, progesterone receptor (PR) status, human epidermal growth factor receptor 2 (HER2) status, BC subtype, surgery, chemotherapy, radiation therapy, and median household income as independent predictors of CVM in BC patients. Conclusions: Compared to the general population, BC patients have a higher risk of experiencing CVM during the follow-up period after diagnosis. Early detection and intervention of cardiovascular risk factors would improve overall survival (OS) of BC patients.
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He et al. (2023) conducted a cohort in Primary breast cancer (n=399,014). Primary breast cancer vs. General population was evaluated on Cardiovascular mortality (SMR 4.84, 95% CI 4.72-4.95). Primary breast cancer was associated with a significantly higher risk of cardiovascular mortality compared to the general population (SMR 4.84; 95% CI 4.72-4.95).
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