Key result
Immune cell infiltration critically drives the pathophysiology of myxomatous, rheumatic, and calcific valve diseases.
Why the study?
Recent studies have identified critical contributions of immune cells to aortic and mitral valve pathophysiology that could be targeted using anti-inflammatory approaches.
Design
Review
Authors
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Hypothesis-generating for immune modulation in valvular heart disease; leaves open whether targeting infiltration improves outcomes.
This review highlights the emerging understanding of immune cell involvement in valvular heart disease pathophysiology and identifies potential anti-inflammatory therapeutic targets.
Gonzalez et al. (2026) conducted a review in Valvular heart disease. Innate and adaptive immune cell infiltration plays a critical role in the pathophysiology of myxomatous valve disease, rheumatic heart disease, and calcific aortic valve disease.
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