Key result
Electroconvulsive therapy induced remission in 42.8% of depressed patients, with psychotic features significantly increasing the likelihood of remission compared to non-psychotic depression (OR 1.94).
Why the study?
What clinical factors are associated with ECT-induced remission in depressed patients?
Cohort (n=1,671)
Yes
What clinical factors are associated with ECT-induced remission in depressed patients?
Effect estimate: OR 1.94 (95% CI 1.41-2.68)
Absolute Event Rate: 63.7% vs 38.4%
p-value: p=<0.001
Psychotic subtype of depression and older age are clinically relevant predictors of a beneficial ECT effect in a community setting.
No takes yet. Share an insight, caveat, or question.
May support psychotic features as ECT predictor in real-world cohorts; leaves open need for randomized confirmation.
Brus et al. (2017) conducted a cohort in Depressive disorders (n=1,671). Electroconvulsive therapy (ECT) vs. Non-psychotic depression was evaluated on Remission (self-rated MADRS-S score of 0-10) (OR 1.94, 95% CI 1.41-2.68, p=<0.001). Electroconvulsive therapy induced remission in 42.8% of depressed patients, with psychotic features significantly increasing the likelihood of remission compared to non-psychotic depression (OR 1.94).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: